Precise and real-time detection of gastrointestinal polyps during endoscopic procedures is crucial for early diagnosis and prevention of colorectal cancer. This work presents En-doSight AI, a deep learning architecture developed and evaluated independently to enable accurate polyp localization and detailed boundary delineation. Leveraging the publicly available Hyper-Kvasir dataset, the system achieves a mean A verage Precision (mAP) of 88.3% for polyp detection and a Dice coefficient of up to 69% for segmentation, alongside real-time inference speeds exceeding 35 frames per second on GPU hardware. The training incorporates clinically relevant performance metrics and a novel thermal-aware procedure to ensure model robustness and efficiency. This integrated AI solution is designed for seamless deployment in endoscopy workflows, promising to advance diagnostic accuracy and clinical decision-making in gastrointestinal healthcare.

To serve global users safely and productively, LLMs need culture-specific knowledge that might not be learned during pre-training. How do we find such knowledge that is (1) salient to in-group users, but (2) unknown to LLMs? The most common solutions are single-initiative: either researchers define challenging questions that users passively answer (traditional annotation), or users actively produce data that researchers structure as benchmarks (knowledge extraction). The process would benefit from mixed-initiative collaboration, where users guide the process to meaningfully reflect their cultures, and LLMs steer the process towards more challenging questions that meet the researcher's goals. We propose a mixed-initiative methodology called CultureCartography. Here, an LLM initializes annotation with questions for which it has low-confidence answers, making explicit both its prior knowledge and the gaps therein. This allows a human respondent to fill these gaps and steer the model towards salient topics through direct edits. We implement this methodology as a tool called CultureExplorer. Compared to a baseline where humans answer LLM-proposed questions, we find that CultureExplorer more effectively produces knowledge that leading models like DeepSeek R1 and GPT-4o are missing, even with web search. Fine-tuning on this data boosts the accuracy of Llama-3.1-8B by up to 19.2% on related culture benchmarks.

Understanding and solving complex reasoning tasks is vital for addressing the information needs of a user. Although dense neural models learn contextualised embeddings, they still underperform on queries containing negation. To understand this phenomenon, we study negation in both traditional neural information retrieval and LLM-based models. We (1) introduce a taxonomy of negation that derives from philosophical, linguistic, and logical definitions; (2) generate two benchmark datasets that can be used to evaluate the performance of neural information retrieval models and to fine-tune models for a more robust performance on negation; and (3) propose a logic-based classification mechanism that can be used to analyze the performance of retrieval models on existing datasets. Our taxonomy produces a balanced data distribution over negation types, providing a better training setup that leads to faster convergence on the NevIR dataset. Moreover, we propose a classification schema that reveals the coverage of negation types in existing datasets, offering insights into the factors that might affect the generalization of fine-tuned models on negation.

Objective: Lung cancer is a leading cause of cancer-related mortality worldwide, primarily due to delayed diagnosis and poor early detection. This study aims to develop a computer-aided diagnosis (CAD) system that leverages large vision-language models (VLMs) for the accurate detection and classification of pulmonary nodules in computed tomography (CT) scans. Methods: We propose an end-to-end CAD pipeline consisting of two modules: (i) a detection module (CADe) based on the Segment Anything Model 2 (SAM2), in which the standard visual prompt is replaced with a text prompt encoded by CLIP (Contrastive Language-Image Pretraining), and (ii) a diagnosis module (CADx) that calculates similarity scores between segmented nodules and radiomic features. To add clinical context, synthetic electronic medical records (EMRs) were generated using radiomic assessments by expert radiologists and combined with similarity scores for final classification. The method was tested on the publicly available LIDC-IDRI dataset (1,018 CT scans). Results: The proposed approach demonstrated strong performance in zero-shot lung nodule analysis. The CADe module achieved a Dice score of 0.92 and an IoU of 0.85 for nodule segmentation. The CADx module attained a specificity of 0.97 for malignancy classification, surpassing existing fully supervised methods. Conclusions: The integration of VLMs with radiomics and synthetic EMRs allows for accurate and clinically relevant CAD of pulmonary nodules in CT scans. The proposed system shows strong potential to enhance early lung cancer detection, increase diagnostic confidence, and improve patient management in routine clinical workflows.

This study proposes a novel perspective on multimodal deep learning for biomedical signal classification, systematically analyzing how complementary feature domains impact model performance. While fusing multiple domains often presumes enhanced accuracy, this work demonstrates that adding modalities can yield diminishing returns, as not all fusions are inherently advantageous. To validate this, five deep learning models were designed, developed, and rigorously evaluated: three unimodal (1D-CNN for time, 2D-CNN for time-frequency, and 1D-CNN-Transformer for frequency) and two multimodal (Hybrid 1, which fuses 1D-CNN and 2D-CNN; Hybrid 2, which combines 1D-CNN, 2D-CNN, and a Transformer). For ECG classification, bootstrapping and Bayesian inference revealed that Hybrid 1 consistently outperformed the 2D-CNN baseline across all metrics (p-values < 0.05, Bayesian probabilities > 0.90), confirming the synergistic complementarity of the time and time-frequency domains. Conversely, Hybrid 2's inclusion of the frequency domain offered no further improvement and sometimes a marginal decline, indicating representational redundancy; a phenomenon further substantiated by a targeted ablation study. This research redefines a fundamental principle of multimodal design in biomedical signal analysis. We demonstrate that optimal domain fusion isn't about the number of modalities, but the quality of their inherent complementarity. This paradigm-shifting concept moves beyond purely heuristic feature selection. Our novel theoretical contribution, "Complementary Feature Domains in Multimodal ECG Deep Learning," presents a mathematically quantifiable framework for identifying ideal domain combinations, demonstrating that optimal multimodal performance arises from the intrinsic information-theoretic complementarity among fused domains.

Computational pathology (CoPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CoPath that are annotated with extensive histological tissue type (HTT) taxonomies at a granular level remain scarce due to the significant expertise and high annotation costs required. Existing datasets, such as the Atlas of Digital Pathology (ADP), address this by offering diverse HTT annotations generalized to multiple organs, but limit the capability for in-depth studies on specific organ diseases. Building upon this foundation, we introduce ADPv2, a novel dataset focused on gastrointestinal histopathology. Our dataset comprises 20,004 image patches derived from healthy colon biopsy slides, annotated according to a hierarchical taxonomy of 32 distinct HTTs of 3 levels. Furthermore, we train a multilabel representation learning model following a two-stage training procedure on our ADPv2 dataset. We leverage the VMamba architecture and achieving a mean average precision (mAP) of 0.88 in multilabel classification of colon HTTs. Finally, we show that our dataset is capable of an organ-specific in-depth study for potential biomarker discovery by analyzing the model's prediction behavior on tissues affected by different colon diseases, which reveals statistical patterns that confirm the two pathological pathways of colon cancer development. Our dataset is publicly available at https://zenodo.org/records/15307021

Indonesia is rich in languages and scripts. However, most NLP progress has been made using romanized text. In this paper, we present NusaAksara, a novel public benchmark for Indonesian languages that includes their original scripts. Our benchmark covers both text and image modalities and encompasses diverse tasks such as image segmentation, OCR, transliteration, translation, and language identification. Our data is constructed by human experts through rigorous steps. NusaAksara covers 8 scripts across 7 languages, including low-resource languages not commonly seen in NLP benchmarks. Although unsupported by Unicode, the Lampung script is included in this dataset. We benchmark our data across several models, from LLMs and VLMs such as GPT-4o, Llama 3.2, and Aya 23 to task-specific systems such as PP-OCR and LangID, and show that most NLP technologies cannot handle Indonesia's local scripts, with many achieving near-zero performance.

The proper planning of different types of public transportation such as metro, highway, waterways, and so on, can increase the efficiency, reduce the congestion and improve the safety of the country. There are certain challenges associated with route planning, such as high cost of implementation, need for adequate resource & infrastructure and resistance to change. The goal of this research is to examine the working, applications, complexity factors, advantages & disadvantages of Floyd- Warshall, Bellman-Ford, Johnson, Ant Colony Optimization (ACO), Particle Swarm Optimization (PSO), & Grey Wolf Optimizer (GWO), to find the best choice for the above application. In this paper, comparative analysis of above-mentioned algorithms is presented. The Floyd-Warshall method and ACO algorithm are chosen based on the comparisons. Also, a combination of modified Floyd-Warshall with ACO algorithm is proposed. The proposed algorithm showed better results with less time complexity, when applied on randomly structured points within a boundary called quasi-structured points. In addition, this paper also discusses the future works of integrating Floyd-Warshall with ACO to develop a real-time model for overcoming above mentioned-challenges during transportation route planning.

The rapid development of Large Language Models (LLMs) and the emergence of novel abilities with scale have necessitated the construction of holistic, diverse and challenging benchmarks such as HELM and BIG-bench. However, at the moment, most of these benchmarks focus only on performance in English and evaluations that include Southeast Asian (SEA) languages are few in number. We therefore propose BHASA, a holistic linguistic and cultural evaluation suite for LLMs in SEA languages. It comprises three components: (1) a NLP benchmark covering eight tasks across Natural Language Understanding (NLU), Generation (NLG) and Reasoning (NLR) tasks, (2) LINDSEA, a linguistic diagnostic toolkit that spans the gamut of linguistic phenomena including syntax, semantics and pragmatics, and (3) a cultural diagnostics dataset that probes for both cultural representation and sensitivity. For this preliminary effort, we implement the NLP benchmark only for Indonesian, Vietnamese, Thai and Tamil, and we only include Indonesian and Tamil for LINDSEA and the cultural diagnostics dataset. As GPT-4 is purportedly one of the best-performing multilingual LLMs at the moment, we use it as a yardstick to gauge the capabilities of LLMs in the context of SEA languages. Our initial experiments on GPT-4 with BHASA find it lacking in various aspects of linguistic capabilities, cultural representation and sensitivity in the targeted SEA languages. BHASA is a work in progress and will continue to be improved and expanded in the future.

Data-to-text (D2T) generation is the task of generating texts from structured inputs. We observed that when the same target sentence was repeated twice, Transformer (T5) based model generates an output made up of asymmetric sentences from structured inputs. In other words, these sentences were different in length and quality. We call this phenomenon "Asymmetric Generation" and we exploit this in D2T generation. Once asymmetric sentences are generated, we add the first part of the output with a no-repeated-target. As this goes through progressive edit (ProEdit), the recall increases. Hence, this method better covers structured inputs Figure 1: An example of generating asymmetric sentences.